Re: mega dose viitamins slow the progression of T1 Diabetes Mellitus

From: William A. Noyes (no.address_at_ctc.net)
Date: 06/08/04 

Date: Mon, 7 Jun 2004 18:33:58 -0700

Ha ha. People can't wait to slap an insult on Jan or Ilena but when it
comes to actually posting a science based comment they go silent.

"William A. Noyes" <no.address@ctc.net> wrote in message
news:40c422cd$0$34766$a32e20b9@news.nntpservers.com...
> Abstract and then comments.
>
> Eur J Endocrinol. 2004 May;150(5):719-24. Related Articles, Links
>
>
> A randomized trial of nicotinamide and vitamin E in children with
> recent onset type 1 diabetes (IMDIAB IX).
>
> Crino A, Schiaffini R, Manfrini S, Mesturino C, Visalli N, Anguissola
> GB, Suraci C, Pitocco D, Spera S, Corbi S, Matteoli MC, Patera IP,
> Manca Bitti ML, Bizzarri C, Pozzilli P; On behalf of the IMDIAB group.
>
> Ospedale Bambino Gesu, Piazza S. Onofrio 4, 00163 Roma, Italy.
>
> OBJECTIVE: Various adjuvant therapies have been introduced along with
> intensive insulin therapy in patients with recent onset type 1
> diabetes. Nicotinamide (NA), administered at diagnosis of the disease,
> can have beneficial effects on the clinical remission rate, improve
> metabolic control and preserve or slightly increase beta-cell
> function, probably by reducing toxicity due to free oxygen radicals.
> Vitamin E, a known antioxidant, inhibits lipid peroxidation; this can
> lead to protection of islet beta cells from the combined effects of
> interleukin 1, tumor necrosis factor and gamma interferon. The aim of
> the present study was to investigate whether the addition of vitamin E
> to NA could improve metabolic control and the residual beta-cell
> function, as measured by C-peptide secretion, in children and
> adolescents with recent onset type 1 diabetes; patients were
> followed-up for 2 years after diagnosis. PATIENTS AND STUDY DESIGN:
> Recent onset type 1 diabetes patients (n=64, mean age 8.8 years) were
> recruited by participating centres of the IMDIAB group. Thirty-two
> patients were randomized to NA (25 mg/kg body weight) plus vitamin E
> (15 mg/kg body weight); 32 patients acted as controls and received NA
> only at the same dose as above. Intensive insulin therapy was applied
> to both treatment groups. RESULTS: There were three drop outs during
> the 2-year follow-up period. Overall, patients assigned to the
> NA+vitamin E group or the NA group did not significantly differ in
> terms of glycated hemoglobin (HbA1c) levels, insulin requirement or
> baseline C-peptide secretion. Patients diagnosed at an age of less
> than 9 years showed significantly reduced C-peptide levels compared
> with those aged over 9 years at diagnosis and at the 2-year follow-up
> but there were no differences between the NA and NA+vitamin E treated
> groups. However at 6 months, patients over 9 years of age treated with
> NA+vitamin E showed significantly higher C-peptide compared with the
> NA group (P<0.003). In both age groups and in the different treatment
> groups, C-peptide levels found at diagnosis were preserved 2 years
> later. CONCLUSIONS: The use of NA alone, or in combination with
> vitamin E, along with intensive insulin therapy is able to preserve
> baseline C-peptide secretion for up to 2 years after diagnosis. This
> finding is of particular interest for pre-pubertal children with type
> 1 diabetes and has never been reported before.
>
> PMID: 15132730 [PubMed - in process]
>
>
>
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=4260677&dopt=Abstract
>
>
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=9437658&dopt=Abstract
>
>
>
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
> ds=12519385&dopt=Abstract
>
>
> First, an explanation for those who don't
> know significance of C-peptide.
>
> "All insulins are composed of A and B
> peptide chains linked by disulfides bonds.
> They are cleaved from proinsulins and two
> dipeptides via reactions that liberate a connecting
> C peptide and two peptides as well as the active hormone.
> Proinsulins are stored in secretory granules,..........
> ..........Circulating C peptide concentrations provide
> a measure of endogenous insulin production in
> individuals treated with hormones from other
> sources (since preparations from other animals do not
> contain it); but C-peptides have longer half-lives. Humans
> have only one insulin type,...................."
> Dictionary of Endocrinology & Related Biomedical Sciences
>
> Hence, the higher levels of the nicotinamide and vitamin E
> is more effective than just nicotinamide and much more
> effective than doing nothing because the higher C-peptides
> levels present in the vitamin combination indicate higher
> levels of native insulin production.
>
> Clearly even if the combination of nicotinamide and
> vitamin E only slows the progress of T1 diabetes it
> is still worth doing. If it only slows the onset by two
> years, it is quite reasonable to assume that
> this will add two years to the lifespan of T1 diabetics.
> The T1 diabetics from the class of "67" are now in
> deep trouble with DM complications. This represents
> a loss for both the individuals and the larger society.
> The use of this vitamin combination is something
> the should be implemented now not later after
> decades of more stalling by medical community
> stick in the muds.
>
> Mega-dose vitamins have their uses.......
> ................................. William A. Noyes
>
> Thank to Tim for posting this abstract earlier.
>
>

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