iron-mediated oxidation of LDL / mortality

From: doe (ironjustice_at_aol.comdoe)
Date: 06/28/04 

Date: 28 Jun 2004 12:40:43 GMT

Fam Med. 2004 May

The combined effect of transferrin saturation and low density lipoprotein on
mortality.

Wells BJ, Mainous AG 3rd, King DE, Gill JM, Carek PJ, Geesey ME.

Department of Family Medicine, Medical University of South Carolina, Charleston
29425, USA. wellsbj@musc.edu

BACKGROUND AND OBJECTIVES: Evidence suggests that cardiovascular disease (CVD)
is accelerated by the oxidation of low-density lipoprotein (LDL) in the
presence of iron. This study examined whether adults with elevated iron, as
measured by transferrin saturation (TS), and elevated LDL are at an increased
risk for mortality. METHODS: This is a cohort study of the adult US population
using the National Health and Nutrition Examination Survey 1976-1980 (NHANES
II) merged with the NHANES II Mortality Study in 1992. Multivariate Cox
regression was performed to determine hazard ratios (HR) for CVD and all-cause
mortality for high (>55%) or low (<55%) levels of TS and high (>160 mg/dl) or
low (<160 mg/dl) levels of LDL. RESULTS: An elevated LDL alone did not
significantly increase CVD mortality or all-cause mortality in the adjusted
model. Individuals with elevated LDL and elevated TS had a statistically
significant increase in both CVD mortality and all-cause mortality (HR=5.74 and
3.53, respectively) compared to the low LDL and low TS group. CONCLUSIONS: The
results of this study indicate an increased risk associated with the
combination of elevated LDL and elevated TS, which suggests that iron-mediated
oxidation of LDL may be a significant factor in the progression of CVD.

http://tinyurl.com/3guhl

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