Re: Cholesterol and Statins continues...

fresh~horses_at_despammed.com
Date: 10/20/04 

Date: 20 Oct 2004 07:22:19 -0700

DP wrote:
> "Ed Mathes" <emathes@rochester.rr.com> je napisal v sporočilo
> news:URsdd.312530$bp1.198174@twister.nyroc.rr.com ...
> >I hope you don't mind, I cross posted this to sci.med.
> >> ***********************************

I do mind. You contacted me personally and I answered you personally.
You didn't ask my permission to post a private e-mail to unsenet. But
since you did post it and only posted part of it, I now post the parts
you omitted:

Dr. Mathes contacting Zee to her private e-mail Tues Oct 19 10 p.m.
MDT

> a BETTER EXAMPLE of drugs that cause gastric disease would be any of
the
> anti-inflammatory (ibuprofen for example), aspirin, fosamax, etc.
The
> patients I have on statins complain of gas, muscle pain, rarely
stomach
> upset.

***********************************

10:30 p.m. MDT Tuesday Oct 19,2004
Salut Dr. Mathes

I do agree those drugs can cause gastric disease. However, so can
statins. Almost daily I hear from people who have had severe side
effects from statins, and gastrointestinal and GI tract disorders,
along with mitochondrial myopathy, are first among their complaints.

I personally experienced nausea, pancreatitis, gall bladder disease,
acid reflux and helicobactor pylori ulcer.

My GI problems were diagnosed when I was on Lipitor. No one suggested
it might be Lipitor. I was slated for gall bladder surgery when I
decided to take myself off because of the muscle pain (with normal
CK--see Phillips below). Within a couple weeks the symptoms were gone.
I had never had GI problems before statin use, nor have I since.

> Nexium, Prilosec (Omeprazole), Aciphex, Protonix, Prevacid ..... did
I miss
All have been shown to heal
> gastric erosions, ulcers, etc.

I question taking a drug which gives you severe symptoms, and then
having to take another to cure (?) them, although in some situations I
agree it's necessary (i.e. Cancer, Hep C)

But I especially question this 'another drug to cure what the first
drug caused' in the case of statins because there is little evidence
for use in primary prevention, and use in secondary prevention is
clouded--to say the least--by conflicts of interests by those
propagating this, and by refusal of the major studies to give negative
information.

I know there are people taking them who say they experience little to
no side effect, and who think statins have saved their lives.

"Do statins have a role in primary prevention?"
http://www.ti.ubc.ca/pages/letter48.htm

*********

Note the comment about half way down from Dr. James Wright head of
Therapeutics Initiative, and a member of the Cochrane Collaboration:

"We've been bamboozled about cholesterol risks"
http://www.healthyskepticism.org/reports/2004/0706.htm

**********

> I personally don't believe Nexium to be any better/more
effective./more
> potent than any other PPI...although some of my colleagues believe it
is.

If you personally don't believe...then you agree with Dr. Peter
Mansfield of Healthy Skepticism, Adelaide University in Australia. Go
here:

http://www.healthyskepticism.org

Click on "What's New" on the left
then scroll down to "dialogue on Nexium" to read Mansfield's discussion
with Astra Zeneca chief Sir Tom McKillop on this subject.

I have a very good friend, among many similarly afflicted whom I know
but don't count as good friends, who has continued to worsen 18 months
after stopping statins. He is a patient of Dr. Paul Phillips of Scripps
Mercy Hospital in San Diego. Below is Phillips website.

Dr. Phillips sees these people who have been told they *may* have
Multiple Sclerosis, ALS, multiple strokes, etc, but Phillips thinks
they do not. He thinks they have been injured by statins.

http://www.impostertrial.com/

I have an article by Phillips on his theory about statin-induced
mitochondrial myopathy. It's not easily copied, and despammed does not
allow attachments. I will send this to you now from another e-mail
address:

{name and e-mail address deleted by Zee}

*********************************

Preclinical safety evaluation of cerivastatin, a novel HMG-CoA
reductase inhibitor.
von Keutz E, Schluter G.

http://tinyurl.com/4d9rt

Institute of Toxicology, PH-Product Development, Bayer AG, Wuppertal,
Germany
Am J Cardiol. 1998 Aug 27;82(4B):11J-17J.
PMID: 9737641
"In dogs, the species most sensitive to statins, cerivastatin caused
erosions and hemorrhages in the gastrointestinal tract, bleeding in the
brain stem with fibroid degeneration of vessel walls in the choroid
plexus, and lens opacity."

**************************

Subchronic toxicity of atorvastatin, a hydroxymethylglutaryl-coenzyme A
reductase inhibitor, in beagle dogs.

http://tinyurl.com/5gpem

Walsh KM, et al
Parke-Davis Pharmaceutical Research, Division of Warner-Lambert
Company, Ann Arbor, Michigan 48105, USA.
"The toxicity of atorvastatin (AT), an inhibitor of
hydroxymethylglutaryl-coenzyme A reductase (HMG), was evaluated in
beagle dogs... hemorrhage in gallbladder and brain, demyelination of
optic nerve, and skeletal muscle necrosis"

*******************************

Not causal relationship but people on statins who have had severe
adverse reaction consistently complain of much here--without ever
having seen this list:

DIGESTIVE SYSTEM:
· ** Nausea
· Gastroenteritis: Inflammation of the stomach and intestines
· Abnormal liver function tests
· Colitis: Inflammation of the colon or large intestine
· Vomiting
· Gastritis: Inflammation of the stomach
· Dry mouth
· Rectal hemorrhage: Heavy bleeding from the rectum
· Esophagitis: Inflammation of the esophagus
· Eructation: Belching, burping
· Glossitis: Inflammation of the tongue
· Mouth ulceration: Ulcers of the mouth
· Anorexia: Lack of appetite for food
· Increased appetite
· Stomatitis: Inflammation of the lining of the mouth
· Biliary pain: Gallbladder pain
· Cheilitis: Inflammation on the lips
· Duodenal ulcer
· Dysphagia: Impaired speech
· Enteritis: Inflammation of the small intestine
· Melena: Bloody stools or vomit
· Gum hemorrhage: Heavy bleeding of the gums
· Stomach ulcer
· Tenesmus: Staining during bowel movements or urination
· Ulcerative stomatitis: Ulcers within the lining of the mouth
· Hepatitis: Inflammation of the liver
· Pancreatitis: Inflammation of the pancreas
· Cholestatic jaundice: Yellowing of the skin due to a stoppage in the
flow of bile

Relevant Pages

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