Rice bran / diabetes
From: doe (ironjustice_at_aol.comdoe)
Date: 11/29/04
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Date: 29 Nov 2004 14:11:42 GMT
Diabetes Res Clin Pract. 2004 Dec;66(Suppl):S157-S160. Related Articles, Links
Rice bran extract prevents the elevation of plasma peroxylipid in KKAy diabetic
mice.
Kanaya Y, Doi T, Sasaki H, Fujita A, Matsuno S, Okamoto K, Nakano Y, Tsujiwaki
S, Furuta H, Nishi M, Tsuno T, Taniguchi H, Nanjo K.
Tsuno Food Industrial Co. Ltd., Kimiidera 811-1, Wakayama, P.O. 641-8509,
Japan.
Oxidative stress is now considered to be a key factor in the development of
diabetes and its complications. In this study, we examined the anti-oxidative
effects of a crude lipophilic rice bran extract, Ricetrienol((R)), which
contains alpha-tocopherol, tocotrienol and phytosterol, in obese diabetic KKAy
mice. We used KKAy mice fed a normal diet (DM group) or a diet including 0.1%
Ricetrienol((R)) (RT group), and non-diabetic C57BL mice (C group). After 6
weeks, body weight, HbA1c, plasma glucose, lipids, peroxylipid
(malonedialdehyde, MDA), alpha-tocopherol and glutathione peroxidase 1 (GPx)
mRNA expression in the kidney were measured. At 1 week and at the end of the
experimental period, urine 8-isoprostane and 8-hydroxy deoxyguanosine (8-OHdG)
were also measured. Ricetrienol((R)) administration did not affect
hyperglycemia, body weight or hyperlipidemia. Plasma MDA, urine 8-isoprostane
and 8-OHdG in the DM group were significantly increased compared with the C
group and the elevation of plasma MDA was significantly suppressed by 0.1%
Ricetrienol. GPx mRNA expression was significantly increased in the RT group
when compared with the C group. Plasma alpha-tocopherol in the RT group was
significantly higher than that in the DM group. These findings suggest that
Ricetrienol((R)) exerts a protective effect against oxidative damage in
diabetes mellitus.
PMID: 15563968 [PubMed - as supplied by publisher]
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