Re: Question about Hypertension & Diabetes?

From: Kumar (lordshiva5753_at_rediffmail.com)
Date: 12/05/04 

Date: 4 Dec 2004 19:59:45 -0800

"Dr. Andrew B. Chung, MD/PhD" <andrew@heartmdphd.com> wrote in message news:<1102189000.yyrzrwEqrIqTxTuLeMgM8Q@teranews>...
> Kumar wrote:
>
> > "Dr. Andrew B. Chung, MD/PhD" <andrew@heartmdphd.com> wrote in message news:<1102161678.kpvK+S/KHQ+VIAfE7Fl6dQ@teranews>...
> > > Kumar wrote:
> > > >
> > > > "Dr. Andrew B. Chung, MD/PhD" <andrew@heartmdphd.com> wrote in message news:<1102071244.i8zz+WWKaSKskq8bm/BDng@teranews>...
> > > > > Kumar wrote:
> > > > > >
> > > > > > nospam6@heartmdphd.com (Dr. Andrew B. Chung, MD/PhD) wrote in message news:<815c94d6.0412021011.12bbc24c@posting.google.com>...
> > > > > > > lordshiva5753@rediffmail.com (Kumar) wrote in message news:<13b3b038.0412010035.272b0d65@posting.google.com>...
> > > > > > > > "Dr. Andrew B. Chung, MD/PhD" <andrew@heartmdphd.com> wrote in message news:<41AC61CE.4CAC@heartmdphd.com>...
> > > > > > > > > Kumar wrote:
> > > > > > > > > >
> > > > > > > > > > "Dr. Andrew B. Chung, MD/PhD" <andrew@heartmdphd.com> wrote in message news:<41A9C761.67ED@heartmdphd.com>...
> > > > > > > > > > > Kumar wrote:
> > > > > > > > > > > >
> > > > > > > > > > > > "Dr. Andrew B. Chung, MD/PhD" <andrew@heartmdphd.com> wrote in message news:<41A8834E.7878@heartmdphd.com>...
> > > > > > > > > > > > > Kumar wrote:
> > > > > > > > > > > > > >
> > > > > > > > > > > > > > "Dr. Andrew B. Chung, MD/PhD" <andrew@heartmdphd.com> wrote in message news:<41A72836.70DC@heartmdphd.com>...
> > > > > > > > > > > > > > > Herman Rubin wrote:
> > > > > > > > > > > > > > > >
> > > > > > > > > > > > > > > > In article <13b3b038.0411241901.4cef5120@posting.google.com>,
> > > > > > > > > > > > > > > > Kumar <lordshiva5753@rediffmail.com> wrote:
> > > > > > > > > > > > > > > > >"Dr. Andrew B. Chung, MD/PhD" <andrew@heartmdphd.com> wrote in message news:<41A49614.BD431EB7@heartmdphd.com>...
> > > > > > > > > > > > > > > > >> Kumar wrote:
> > > > > > > > > > > > > > > >
> > > > > > > > > > > > > > > > ...................
> > > > > > > > > > > > > > > >
> > > > > > > > > > > > > > > > >quote:
> > > > > > > > > > > > > > > > >--------------------------------------------------------------------------------
> > > > > > > > > > > > > > > > >More commonly, people will develop insulin resistance (Type 2
> > > > > > > > > > > > > > > > >Diabetes) rather than a true deficiency of insulin. In this case, the
> > > > > > > > > > > > > > > > >levels of insulin in the blood are similar or even a little higher
> > > > > > > > > > > > > > > > >than in normal, non-diabetic individuals. However, many cells of Type
> > > > > > > > > > > > > > > > >2 diabetics respond sluggishly to the insulin they make and therefore
> > > > > > > > > > > > > > > > >their cells cannot absorb the sugar molecules well. This leads to
> > > > > > > > > > > > > > > > >blood sugar levels which run higher than normal. Occasionally Type 2
> > > > > > > > > > > > > > > > >diabetics will need insulin shots but most of the time other methods
> > > > > > > > > > > > > > > > >of treatment will work.
> > > > > > > > > > > > > > > > >http://www.endocrineweb.com/diabetes/2insulin.html
> > > > > > > > > > > > > > > > >--------------------------------------------------------------------------------
>
> > > > > > > > > > > > > > > > >Under above consideration, I do not understand why oral hypogymic
> > > > > > > > > > > > > > > > >medicines or insulin is commonly prescribed. Insulin level in blood
> > > > > > > > > > > > > > > > >can be higher in blood due to insulin resistance, then what is the use
> > > > > > > > > > > > > > > > >of furthur raising its level by medications?
> > > > > > > > > > > > > > > >
> > > > > > > > > > > > > > > > When the house gets too drafty, one should close the windows
> > > > > > > > > > > > > > > > or improve the insulation. If that is not possible, put more
> > > > > > > > > > > > > > > > fuel on the fire.
> > > > > > > > > > > > > > > >
> > > > > > > > > > > > > > > > Most biochemical activities can be pushed by overloading the
> > > > > > > > > > > > > > > > amount of one of the reactants, just as if a door is poorly
> > > > > > > > > > > > > > > > lubricated, pushing harder can make it work.
> > > > > > > > > > > > > > > >
> > > > > > > > > > > > > > >
> > > > > > > > > > > > > > > Well written. Would concur :-)
> > > > > > > > > > > > > > >
> > > > > > > > > > > > > > >
> > > > > > > > > > > > > > > Servant to the humblest person in the universe,
> > > > > > > > > > > > > > >
> > > > > > > > > > > > > > > Andrew
> > > > > > > > > > > > > > >
> > > > > > > > > > > > > > > --
> > > > > > > > > > > > > > > Dr. Andrew B. Chung, MD/PhD
> > > > > > > > > > > > > > > Board-Certified Cardiologist
> > > > > > > > > > > > > > > http://www.heartmdphd.com/
> > > > > > > > > > > > > > >
> > > > > > > > > > > > > > > **
> > > > > > > > > > > > > > > Who is the humblest person in the universe?
> > > > > > > > > > > > > > > http://makeashorterlink.com/?L26062048
> > > > > > > > > > > > > > >
> > > > > > > > > > > > > > > What is all this about?
> > > > > > > > > > > > > > > http://makeashorterlink.com/?R20632B48
> > > > > > > > > > > > > > >
> > > > > > > > > > > > > > > Is this spam?
> > > > > > > > > > > > > > > http://makeashorterlink.com/?N69721867
> > > > > > > > > > > > > >
> > > > > > > > > > > > > > Thanks,
> > > > > > > > > > > > >
> > > > > > > > > > > > > You are welcome.
> > > > > > > > > > > > >
> > > > > > > > > > > > > All praises go to my heavenly Father, Whom I love with all my heart,
> > > > > > > > > > > > > soul, mind, and strength :-)
> > > > > > > > > > > > >
> > > > > > > > > > > > >
> > > > > > > > > > > > > > but it seems to be common thought.
> > > > > > > > > > > > >
> > > > > > > > > > > > > Herman Rubin has God's gift of eloquence for the written word so that
> > > > > > > > > > > > > thoughts are conveyed so clearly as to seem "common."
> > > > > > > > > > > > >
> > > > > > > > > > > > >
> > > > > > > > > > > > > > How adding more insulin to
> > > > > > > > > > > > > > already excess insulin can produce such effects bio-chemically.
> > > > > > > > > > > > >
> > > > > > > > > > > > > There are chemical reaction equations that would explain this.
> > > > > > > > > > > > >
> > > > > > > > > > > > > > It
> > > > > > > > > > > > > > looks more logical that excess insulin & BG should cause alike more
> > > > > > > > > > > > > > indigetion or unwillingness of taking these by target cells.
> > > > > > > > > > > > >
> > > > > > > > > > > > > Cells do not suffer from indigestion. When they become loaded with
> > > > > > > > > > > > > excess glucose, they do start down-regulating the number of insulin
> > > > > > > > > > > > > receptors on their surfaces.
> > > > > > > > > > > > >
> > > > > > > > > > > > > > Insulin
> > > > > > > > > > > > > > being more complex,bigger molecule & may be toxic in excess(BG may not
> > > > > > > > > > > > > > because a regular food & simpler molecule)should be the first
> > > > > > > > > > > > > > canditate for resistance by target cells than glucose.
> > > > > > > > > > > > >
> > > > > > > > > > > > > Insulin (a polypeptide) does not enter the cells as glucose does.
> > > > > > > > > > > > >
> > > > > > > > > > > > > May God bless you today, dear Kumar whom I love, in Christ's holy name.
> > > > > > > > > > > > >
> > > > > > > > > > > > >
> > > > > > > > > > > > > Servant to the humblest person in the universe,
> > > > > > > > > > > > >
> > > > > > > > > > > > > Andrew
> > > > > > > > > > > > >
> > > > > > > > > > > > > --
> > > > > > > > > > > > > Dr. Andrew B. Chung, MD/PhD
> > > > > > > > > > > > > Board-Certified Cardiologist
> > > > > > > > > > > > > http://www.heartmdphd.com/
> > > > > > > > > > > > >
> > > > > > > > > > > > > **
> > > > > > > > > > > > > Who is the humblest person in the universe?
> > > > > > > > > > > > > http://makeashorterlink.com/?L26062048
> > > > > > > > > > > > >
> > > > > > > > > > > > > What is all this about?
> > > > > > > > > > > > > http://makeashorterlink.com/?R20632B48
> > > > > > > > > > > > >
> > > > > > > > > > > > > Is this spam?
> > > > > > > > > > > > > http://makeashorterlink.com/?N69721867
> > > > > > > > > > > >
> > > > > > > > > > > > "Cells do not suffer from indigestion. When they become loaded with
> > > > > > > > > > > > excess glucose, they do start down-regulating the number of insulin
> > > > > > > > > > > > receptors on their surfaces."
> > > > > > > > > > > >
> > > > > > > > > > > > What happens to these insulin receptors when cells become normar or
> > > > > > > > > > > > deficient to glucose exposure?
> > > > > > > > > > >
> > > > > > > > > > > The opposite.
> > > > > > > > > > >
> > > > > > > > > > > > Can't this down-regulating of number of
> > > > > > > > > > > > insulin receptors be due to excess insulin load instead of glucose?
> > > > > > > > > > >
> > > > > > > > > > > It can but isn't.
> > > > > > > > > > >
> > > > > > > > > > >
> > > > > > > > > > > > Calcium channel blocker a medicine for hypertension causes increase in
> > > > > > > > > > > > blood sugar level. Can we then think that,calcium can be related to
> > > > > > > > > > > > insulin resistance?
> > > > > > > > > > >
> > > > > > > > > > > No. Insulin resistance would be suspected only when it can be
> > > > > > > > > > > demonstrated that there are higher levels of blood glucose despite
> > > > > > > > > > > higher levels of insulin.
> > > > > > > > > > >
> > > > > > > > > > > May God bless you on this Lord's day, dear Kumar whom I love, in
> > > > > > > > > > > Christ's holy name.
> > > > > > > > > > >
> > > > > > > > > > > Servant to the humblest person in the universe,
> > > > > > > > > > >
> > > > > > > > > > > Andrew
> > > > > > > > > > >
> > > > > > > > > > > --
> > > > > > > > > > > Dr. Andrew B. Chung, MD/PhD
> > > > > > > > > > > Board-Certified Cardiologist
> > > > > > > > > > > http://www.heartmdphd.com/
> > > > > > > > > > >
> > > > > > > > > > > **
> > > > > > > > > > > Who is the humblest person in the universe?
> > > > > > > > > > > http://makeashorterlink.com/?L26062048
> > > > > > > > > > >
> > > > > > > > > > > What is all this about?
> > > > > > > > > > > http://makeashorterlink.com/?R20632B48
> > > > > > > > > > >
> > > > > > > > > > > Is this spam?
> > > > > > > > > > > http://makeashorterlink.com/?N69721867
> > > > > > > > > >
> > > > > > > > > > thanks.
> > > > > > > > >
> > > > > > > > > You are welcome. All praises belong to my heavenly Father Whom I love
> > > > > > > > > with all my being :-)
> > > > > > > > >
> > > > > > > > > > Both insulin & glucose are exposed in excess totarget cells
> > > > > > > > > > in insulin resistance coditions.
> > > > > > > > >
> > > > > > > > > Not a true depiction. Exposure suggests that there insulin and glucose
> > > > > > > > > are variables being manipulated by someone or something in an
> > > > > > > > > unregulated fashion.
> > > > > > > > >
> > > > > > > > >
> > > > > > > > > > How you can decide that it is BG not
> > > > > > > > > > insulin which results dawn regulating of recepors?
> > > > > > > > >
> > > > > > > > > You do the experiments through research.
> > > > > > > > >
> > > > > > > > >
> > > > > > > > > > Is is not correct that after some time all insulin resistant patients
> > > > > > > > > > become non insulin resistant or type1?
> > > > > > > > >
> > > > > > > > > No. It is not correct. Type 2 diabetes remain type 2 even if they
> > > > > > > > > start requiring insulin because of beta cell failure.
> > > > > > > > >
> > > > > > > > >
> > > > > > > > > > How, when BG level remains
> > > > > > > > > > always higher ev at later stages?
> > > > > > > > >
> > > > > > > > > Blood glucose level is a function of many things.
> > > > > > > > >
> > > > > > > > >
> > > > > > > > > > How hyperglycemia is possible with excess dose of medicine or injected
> > > > > > > > > > insulin in view of total glucose level in body(not in blood) remains
> > > > > > > > > > same?
> > > > > > > > >
> > > > > > > > > Insulin resistance. Total body glucose is not invariant.
> > > > > > > > >
> > > > > > > > >
> > > > > > > > >
> > > > > > > > > Servant to the humblest person in the universe,
> > > > > > > > >
> > > > > > > > > Andrew
> > > > > > > > >
> > > > > > > > > --
> > > > > > > > > Dr. Andrew B. Chung, MD/PhD
> > > > > > > > > Board-Certified Cardiologist
> > > > > > > > > http://www.heartmdphd.com/
> > > > > > > > >
> > > > > > > > > **
> > > > > > > > > Who is the humblest person in the universe?
> > > > > > > > > http://makeashorterlink.com/?L26062048
> > > > > > > > >
> > > > > > > > > What is all this about?
> > > > > > > > > http://makeashorterlink.com/?R20632B48
> > > > > > > > >
> > > > > > > > > Is this spam?
> > > > > > > > > http://makeashorterlink.com/?N69721867
> > > > > > > >
> > > > > > > > "No. It is not correct. Type 2 diabetes remain type 2 even if they
> > > > > > > > start requiring insulin because of beta cell failure."
> > > > > > > >
> > > > > > > > Is there any stage in type2 patients with insulin resistance, when
> > > > > > > > insulin resistance is no more?
> > > > > > >
> > > > > > > When/if they become lean.
> > > > > > >
> > > > > > > > I mean whether IR condition is life
> > > > > > > > long or reduces as diabetes progress with the age or when beta cells
> > > > > > > > are no more able to produce any insulin.
> > > > > > > >
> > > > > > > > "Insulin resistance. Total body glucose is not invariant."
> > > > > > > >
> > > > > > > > Do you mean IR can be a cause to hypoglycemea?
> > > > > > >
> > > > > > > No.
> > > > > > >
> > > > > > > > Whether hypoglycemea is
> > > > > > > > experianced due to less BG or due to less/not going into cells?
> > > > > > >
> > > > > > > Your question is not clear.
> > > > > > >
> > > > > > > > Furthur, under Hormone receptor regulation as per below link, it looks
> > > > > > > > hormones are responsible for receptors regulations. Why then insulin
> > > > > > > > can't act as receptor's regulator?
> > > > > > > > http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=endocrin.section.33
> > > > > > >
> > > > > > > Symptomatic hypoglycemia keeps insulin levels from ever being
> > > > > > > excessive enough to down-regulate its receptor.
> > > > > > >
> > > > > > > > Best wishes.
> > > > > > >
> > > > > > > Same for you.
> > > > > > >
> > > > > > > Servant to the humblest person in the universe,
> > > > > > >
> > > > > > > Andrew
> > > > > > >
> > > > > > > --
> > > > > > > Dr. Andrew B. Chung, MD/PhD
> > > > > > > Board-Certified Cardiologist
> > > > > > > http://www.heartmdphd.com/
> > > > > > >
> > > > > > > **
> > > > > > > Who is the humblest person in the universe?
> > > > > > > http://makeashorterlink.com/?L26062048
> > > > > > >
> > > > > > > What is all this about?
> > > > > > > http://makeashorterlink.com/?R20632B48
> > > > > > >
> > > > > > > Is this spam?
> > > > > > > http://makeashorterlink.com/?N69721867
>
> > > > > > > "Whether hypoglycemea is
> > > > > > > experianced due to less BG or due to less/not going into cells?"
>
> > > > > > >>Your question is not clear<<
> > > > > >
> > > > > > I mean that Whether hypoglycemia symptoms are felt by a patient due to
> > > > > > glucose real deficiency in blood or/and couldn't being used by cells
> > > > > > due to insulin resitance condition?
> > > > >
> > > > > The former.
> > > > >
> > > > >
> > > > > Servant to the humblest person in the universe,
> > > > >
> > > > > Andrew
> > > > >
> > > > > --
> > > > > Dr. Andrew B. Chung, MD/PhD
> > > > > Board-Certified Cardiologist
> > > > > http://www.heartmdphd.com/
> > > > >
> > > > > **
> > > > > Who is the humblest person in the universe?
> > > > > http://makeashorterlink.com/?L26062048
> > > > >
> > > > > What is all this about?
> > > > > http://makeashorterlink.com/?R20632B48
> > > > >
> > > > > Is this spam?
> > > > > http://makeashorterlink.com/?N69721867
> > > >
> > > > Thanks.
> > >
> > > You are welcome. All praises belong to my heavenly Father, Whom I love
> > > with all my heart, soul, mind, and strength :-)
> > >
> > > > Sulphur is the part of Diabetes oral medicines & insulin. How Sulphur
> > > > is related to diabetes?
> > >
> > > There is no known association.
> > >
> > > > Can it be possible/thought that low level of total cholesterol (say
> > > > less than 140 mg/dl) can be linked to insulin resistance or persistant
> > > > high BG levels?
> > >
> > > There is no known association. High triglycerides would be a different
> > > story however.
> > >
> > > > Best wishes.
> > >
> > > For you as well.
> > >
> > >
> > > Servant to the humblest person in the universe,
> > >
> > > Andrew
> > >
> > > --
> > > Dr. Andrew B. Chung, MD/PhD
> > > Board-Certified Cardiologist
> > > http://www.heartmdphd.com/
> > >
> > > **
> > > Who is the humblest person in the universe?
> > > http://makeashorterlink.com/?L26062048
> > >
> > > What is all this about?
> > > http://makeashorterlink.com/?R20632B48
> > >
> > > Is this spam?
> > > http://makeashorterlink.com/?N69721867
> >
> > Furthur you said;
> >
> > "Cells do not suffer from indigestion. When they become loaded with
> > excess glucose, they do start down-regulating the number of insulin
> > receptors on their surfaces."
> >
> > What happens to these insulin receptors when cells become normar or
> > deficient to glucose exposure?
>
> >
> > "The opposite."
> >
> > Will then fasting/discontinuing glucose for some time not reverse
> > insulin resistance condition?
>
> There is no way to discontinue glucose even with zero intake (fasting). The body breaks down structural proteins to make glucose
> (gluconeogenesis).
>
> Insulin resistance is reversed by loss of adiposity.
>
>
> Servant to the humblest person in the universe,
>
> Andrew
>
> --
> Dr. Andrew B. Chung, MD/PhD
> Board-Certified Cardiologist
> http://www.heartmdphd.com/
>
> **
> Who is the humblest person in the universe?
> http://makeashorterlink.com/?L26062048
>
> What is all this about?
> http://makeashorterlink.com/?R20632B48
>
> Is this spam?
> http://makeashorterlink.com/?N69721867

I meant by reduing overall level of glucose. Does the loss of
adiposity not somewhat alike loss of overall level of glucose?.

Furthur, whether sulphur gets freed from disulphide bond in insulin
molecule duting the process of insulin use?

Relevant Pages

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