Infertile men / oxidation

ironjustice_at_aol.com
Date: 01/30/05 

Date: 30 Jan 2005 12:23:36 -0800

I guess this would give credence to Dr. Shutes' decades old theories as
to Vitamin E for infertility .. the 'fertility vitamin' ..

Eh ..

Arch Androl. 2004 Nov-Dec;50(6):411-6. Related Articles, Links

Analysis of lipid peroxidative levels in seminal plasma of infertile
men by high-performance liquid chromatography.

Shang XJ, Li K, Ye ZQ, Chen YG, Yu X, Huang YF.

Laboratory of Reproduction & Genetics, Jinling Hospital, Nanjing, PR
China. xjshang@ntl-j-androl.com

For the purpose to evaluate the significance of lipid peroxidative
products on male infertility, the levels of malondialdehyde (MDA),
which is one of the final products of lipid peroxidation in seminal
plasma, were determined. Ninety-three male infertile patients were
divided into obstructive azoospermic group (12 cases), non-obstructive
azoospermic group (15 cases), oligozoospermic group (21 cases),
asthenozoospermic group (19 cases), oligoasthenozoospermic group (16
cases) and oligoasthenoteratozoospermic group (10 cases). Eighteen
fertile males were included in the control group. MDA concentrations of
seminal plasma in the fertile and infertile men were detected by
high-performance liquid chromatography (HPLC). The results showed that
the concentration of MDA in seminal plasma differed significantly
between the control group and all the infertile groups (P < 0.01)
except the obstructive azoospermic group, between the
oligoasthenozoospermic group and the oligozoospermic and
asthenozoospermic groups (P < 0.01), and between the
oligoasthenoteratozoospermic group and the oligozoospermic and
asthenozoospermic groups (P < 0.01). MDA concentration of seminal
plasma in the oligoasthenoteratozoospermic group differed significantly
from that in the oligoasthenozoospermic group (P <0.05). The results
suggested that detection of MDA concentrations in seminal plasma by
HPLC has an indicative value on the diagnosis of male infertility
induced by overproduction of reactive oxygen species in male
reproductive system.

PMID: 15669606 [PubMed - in process]

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Tom

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