Substantial oxidative stress / Diabetes Mellitus type I

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Date: 02/27/05 

Date: 27 Feb 2005 11:38:58 -0800

Pharmacol Res. 2005 Apr;51(4):375-80. Related Articles, Links

Altered redox status in patients with Diabetes Mellitus type I.

Gil-Del Valle L, Milian Lde L, Toledo A, Vilaro N, Tapanes R, Otero MA.

Department of Clinical Pharmacology, Institute of Tropical Medicine
"Pedro Kouri" (IPK), P.O. Box 601, Marianao 13, Ciudad de La Habana,
Cuba.

Diabetes mellitus is a complex metabolic disorder characterized by a
disturbance in glucose metabolism. Recent evidences suggest that
increased oxidative damage as well as deficits in antioxidants defence
systems could be related to the complications in Diabetes patients'
type I. The aim of this study was to investigate an extensive array of
redox status indices: glutathione (GSH), malondialdehyde (MDA),
peroxidation potential, superoxide dismutase (SOD), catalase (CAT),
total hydroperoxide (TH) and advanced oxidation protein products (AOPP)
in relation to blood glucose and glucose indicators control such as
glycosylated haemoglobin (HbA(1c)) and fructosamine by
spectophotometric techniques. Forty Diabetes Mellitus patients' type I
and 40 healthy subjects were recruited. Both a reduction of GSH levels
and an increase in MDA and TH levels were observed in the serum of
patients. These patients also showed an increase of AOPP and PP levels
as well as an increase of both CAT and SOD activity. Relatively to the
control group, patients had significant differences in global indices
of oxidant/antioxidant status and indicators of glycaemia control.
These results contribute both to the evidences that substantial
oxidative stress occurs during Diabetes Mellitus type I without early
complications and to an integral overview of the oxidant/antioxidant
balance in these patients.

PMID: 15683752 [PubMed - in process]

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