N-acetylcysteine / colitis
ironjustice_at_aol.com
Date: 03/27/05
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Date: 27 Mar 2005 12:21:41 -0800
J Int Med Res. 2005 Mar-Apr;33(2):196-206. Related Articles, Links
Effects of N-acetylcysteine treatment on oxidative stress in acetic
acid-induced experimental colitis in rats.
Akgun E, Caliskan C, Celik HA, Ozutemiz AO, Tuncyurek M, Aydin HH.
Department of General Surgery, Ege University School of Medicine,
Bornova, Izmir, Turkey. eakgun@med.ege.edu.tr
We assessed the possible protective effects of N-acetylcysteine (NAC)
against toxic damage in the rat colon. Two doses of NAC (20 mg/kg and
100 mg/kg) given for 2 days and 7 days after acetic acid administration
(to induce colitis) were tested. NAC was dissolved in saline and
administered locally (intracolonic), systemically (intraperitoneal) or
in a combination (intracolonic and intraperitoneal). Several
parameters, including macroscopic and histopathological scores and
myeloperoxidase, glutathione and nitric oxide concentrations were
measured using standard assay procedures. Treatment with 100 mg/kg NAC
for 7 days significantly decreased tissue myeloperoxidase, glutathione
and nitric oxide concentrations. The 20 mg/kg dose had no protective
effects. The data indicate that NAC substantially reduced the degree of
colonic injury, probably by regulating free radical production and
inhibiting inflammation. It may, therefore, have a role in the
treatment of inflammatory bowel disease.
PMID: 15790131 [PubMed - in process]
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