Re: N-acetylcysteine / colitis
From: Ken.W (phosgate_at_telus.net)
Date: 03/28/05
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Date: Mon, 28 Mar 2005 00:36:35 GMT
IT'S BEEN A PART OF MY NUTRIONAL REGIMEN FOR YEARS.
<ironjustice@aol.com> wrote in message
news:1111954901.926211.288620@g14g2000cwa.googlegroups.com...
>J Int Med Res. 2005 Mar-Apr;33(2):196-206. Related Articles, Links
>
>
> Effects of N-acetylcysteine treatment on oxidative stress in acetic
> acid-induced experimental colitis in rats.
>
> Akgun E, Caliskan C, Celik HA, Ozutemiz AO, Tuncyurek M, Aydin HH.
>
> Department of General Surgery, Ege University School of Medicine,
> Bornova, Izmir, Turkey. eakgun@med.ege.edu.tr
>
> We assessed the possible protective effects of N-acetylcysteine (NAC)
> against toxic damage in the rat colon. Two doses of NAC (20 mg/kg and
> 100 mg/kg) given for 2 days and 7 days after acetic acid administration
> (to induce colitis) were tested. NAC was dissolved in saline and
> administered locally (intracolonic), systemically (intraperitoneal) or
> in a combination (intracolonic and intraperitoneal). Several
> parameters, including macroscopic and histopathological scores and
> myeloperoxidase, glutathione and nitric oxide concentrations were
> measured using standard assay procedures. Treatment with 100 mg/kg NAC
> for 7 days significantly decreased tissue myeloperoxidase, glutathione
> and nitric oxide concentrations. The 20 mg/kg dose had no protective
> effects. The data indicate that NAC substantially reduced the degree of
> colonic injury, probably by regulating free radical production and
> inhibiting inflammation. It may, therefore, have a role in the
> treatment of inflammatory bowel disease.
>
> PMID: 15790131 [PubMed - in process]
>
> --------------------------------------------------------------------------------
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!
> http://herbivore.7h.com
>
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