Re: Questions: Angiogenesis in Cancer

"If only things were so simple -- if only immune systems could be
simply
characterised as "strong" or "weak", like muscles!"

Many thanks for quite imformative reply. Anyhow, I feel some problem in
our understanding of immune system's role in cancer & other latencies.

"The really hard part is that a cancer isn't like an infection. It's
made up of your own cells, which your body will and should identify as
"self" not "invader". Is an immune system "strong" or "weak" when it
gets confused about self and other and attacks normal tissues, causing
disease like type 1 diabetes, multiple sclerosis, rheumatoid arthritis,

lupus and many others?"

Is it not in some very earlier stage of getting cancer that it is
difficult to differenciate the cancer cells with our cells? I think,
getting cancer cells encapsuled in tumor, indicate that immune system
has recognized them & started working on that alike other latencies.
Otherwise why tumor formation will take place?


"Immunotherapies for cancers are continually being developed. The idea

is to get the patient's immune system to regard the cancer as "alien"
and attack it. These methods are always promising, but never good
enough to get into standard use. But the effort is certainly
worthwhile, even though it's known that cancers will mutate fast enough

to evade even an immune system that has been sensitized to them.
Further research may result in more reliable immunotherapies."

I think numbers of angiogenesis stimulators & inhibitor may be
mediated by immune system--when it is strong, more can be the
inhibitors and when weak, more can be the stimulators in normal
circumstances. I am not sure if stimulators can be encouraged on
improved immunity to promote angiogenesis as I indicated previously. It
looks to me that we are bit unclear about, what happens on getting
improved/strong immune system as we may mistake or fear not to take
chances as there can be somewhat similar symptoms of spread/coming out
of cancer cells from tumor if encouraged by improved immunity or is
cancer is progressed. Truma, stress, infections etc may again weaken
immune system & these may interfere in natural cure on improved
immunity.

"The immune system is believed to be involved in suppressing virally
induced cancers at an early stage. We have an experiment of nature in
the form of the several viral-caused cancers that are so common in HIV+

individuals. People who take immune-suppression drugs in connection
with organ transplants also develop cancers at an unusually high rate.
Cancer is mainly a disease of older people, and the immune system
becomes less effective with age, although this particular correlation
is not the best evidence for causation. "

All these tell me that, it is weak or strong immune system that works
or not work on cancer.


"AFAIK, the best theory about spontaneous remissions is that the
patient's immune system suddenly decides that the cancer is alien, and
attacks and destroys it as an invader. Immunotherapy is an effort to
induce this effect artificially, and it's a very active area of
research. It's not simple, because finding a marker the immune system
can identify, that isn't found on any normal cell, is not trivial."

As I indicated, I think immune system understand the cancer cells
different from normal cells which causes tumor formations. But the
problem can be that who will take chance & how to check, whether immune
system is suitably strong or not to handle cancer cells?


"As far as angiogenesis, the immune system acts through white blood
cells and antibodies carried in the blood. If a tissue has no blood
supply, the immune system can't act in it. But a tissue with no blood
supply isn't going to grow, or in most cases, survive. A tumor that
can express angiogenesis promoting factors will survive and grow. Most

cancers aren't very good at providing themselves with an effective
blood supply throughout and die at the core of the tumor, resulting in
the appalling smell many cancer patients develop as the dead tissue
breaks down while the tumor continues to grow nearer its surface, and
in metastatic tumors which have a higher ratio of surface to volume."

It is very relevant to my doubts. How immunotherapy or naturally
strengthened immune system can work when cancer cells are still in
tumor? Tumor formations can be a immune system's work meant for--to
starve cancer cells OR to restrict & resist their growth OR to wait &
prepare for right time of suitably strengthened immune system. It may
be mediated via angiogenesis inhibitions.

.

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