schizophrenia and DHEA
- From: James Michael Howard <jmhoward@xxxxxxxxxxxxxxxx>
- Date: Tue, 30 Aug 2005 15:00:08 GMT
Schizophr Res. 2005 Aug 25; [Epub ahead of print]
Improvement of extrapyramidal symptoms following dehydroepiandrosterone (DHEA)
administration in antipsychotic treated schizophrenia patients: A randomized,
double-blind placebo controlled trial.
Nachshoni T, Ebert T, Abramovitch Y, Assael-Amir M, Kotler M, Maayan R, Weizman
A, Strous RD.
Beer Yaakov Mental Health Center, PO Box 1, Beer Yaakov 70350, Israel.
Recent investigation in schizophrenia indicated dehydroepiandrosterone (DHEA)
levels to be inversely correlated with extrapyramidal symptomatology (EPS). This
study thus investigates the effect of DHEA administration on medication-induced
EPS. Inpatients with schizophrenia or schizoaffective disorder were randomized
in double-blind fashion to receive either 100 mg DHEA or placebo in addition to
a constant dosage of antipsychotic medication. Parkinsonism showed a favorable
effect of DHEA with a significant time effect (p<0.0001), as well as a
significant group by time interaction (p<0.05) and with no change noted on
akathisia. Change of DHEA blood levels was negatively associated with change of
Parkinsonism (p<0.05) as well as with change of total EPS ratings (p<0.05). DHEA
appears to demonstrate a significant effect on EPS, with improvement observed
particularly in Parkinsonian symptoms.
.
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