DHEA and mortality
- From: James Michael Howard <jmhoward@xxxxxxxxxxxxxxxx>
- Date: Tue, 31 Jan 2006 16:53:35 GMT
Ann Epidemiol. 2006 Jan 26; [Epub ahead of print]
Dehydroepiandrosterone Sulfate (DHEAS) and Risk for Mortality Among Older
Taiwanese.
Glei DA, Goldman N.
>From the Department of Demography, University of California, Berkeley, CA
(D.A.G.); and Office of Population Research, Princeton University,
Princeton, NJ (N.G.).
PURPOSE: Studies based on Western populations showed a negative
relationship between dehydroepiandrosterone sulfate (DHEAS) level and
mortality, but no study examined this relationship in a non-Western
country. We use data from a large, nationally representative sample (n =
963) of older Taiwanese to investigate whether serum DHEAS, predicts
subsequent mortality during a 3-year period (2000 to 2003) and whether an
effect remains after controlling for baseline health status. METHODS:
Baseline data collection included an individual interview, physical
examination, and blood sample. A logit model is used to test the
relationship between DHEAS level and risk for mortality, controlling for
age, sex, and smoking status. RESULTS: Results show a marginally
significant inverse relationship between DHEAS level and 3-year mortality
risk. Participants with low DHEAS levels (<54.5 mug/dL) have 64% greater
odds of dying than those with higher DHEAS levels (p < 0.06). After
adjusting for various indicators of health status in 2000, the odds ratio
(OR) for low DHEAS level remains substantial (OR = 1.41), but not
statistically significant. CONCLUSIONS: Although the analysis is limited by
the short follow-up and small number of deaths, results are consistent with
the notion that DHEAS level has a sizeable effect on mortality.
.
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