Re: Help ! Anybody knows solutions for progressive bulbar paralysis ?


Xufei.Wang@xxxxxxxxx wrote:
Dears

My friend got such a disease - progressive bulbar paralysis recently, I
am not a doctor, what I know is only the name of the disease -
progressive bulbar paralysis, it seems serious. Now her tongue is
becoming rigid, hard to swallow foods and water.
The doctor here suggested some traditional Chinese medicine and
threrapies.

But I am afraid it takes effect much slower, does anybody here know
any medchine or therapy method I can get for that ?

Hope your help !!


wang

This first study speaks to the finding of ataxia , deafness in this
problem.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7362486&dopt=Abstract

This closely mimics the effects of increased iron levels .. superficial
siderosis .. neurodegenerative disease of iron dishomeostasis or
neurodegenerative disease with brain iron accumulation.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9292135&dopt=Abstract

The iron would seem to be the problem.
They have shown the application of vegetable oil to the skin allows the
ingredients in the oil to enter the body.

http://www.indianpediatrics.net/oct2005/oct-998-1005.htm

In soil remediation for heavy metals .. the substances / sugars /
phosphates which pass the skin / enter into the body are used for
removal / sequestration of metals .. presently for lead in old gasoline
sites and further it seems to .. uranium.

http://www.biotech-weblog.com/50226711/soil_subsurface_bacteria_potential_aid_in_uranium_contamination.php

Soooo .. you might consider oiling up / massaging your friend every six
hours for at least a week .. as per evidence based medicine ..

"Oil application: Five mL of the study oil was massaged on all
available surfaces of the baby four times a day. "

Arch Neurol. 1980 Apr;37(4):214-6. Related Articles, Links


Progressive bulbar paralysis associated with neural deafness. A
nosological entity.

Alberca R, Montero C, Ibanez A, Segura DI, Miranda-Nieves G.

A complete autopsy verification of progressive bulbar palsy associated
with neural deafness was performed. Hearing loss and speech
difficulties developed in a five-year-old girl. When she was 24 years
old, clinical examination demonstrated deafness and bulbopontine
paralysis together with retinitis pigmentosa, peripheral amyotrophies,
pyramidal signs, and ataxia. The patients died at 27 years and the
autopsy disclosed degenerative changes characterized by simple atrophy
and loss of neurons accompanied by gliosis and loss of myelinated
fibers. The structures principally affected were the anterior horns and
the motor nuclei of the brain stem together with the eighth cranial
nerve nuclei. Loss of myelinated fibers was found in the
spinocerebellar and pyramidal tracts and in the fasciculus gracilis.
Our study suggests that progressive bulbar paralysis with neural
deafness should be considered as a nosological entity.

Publication Types:
Case Reports

PMID: 7362486 [PubMed - indexed for MEDLINE]

----------------------------------------------------------------------------------


J Laryngol Otol. 1997 Jan;111(1):60-2. Related Articles, Links


Superficial siderosis of the central nervous system: an underestimated
cause of hearing loss.

Castelli ML, Husband A.

Department of Otorhinolaryngology, Queen Alexandra Hospital, Cosham,
Portsmouth, UK.

Superficial siderosis of the central nervous system (CNS) is a rare
disease resulting in the accumulation of haemosiderin in the meninges,
the brain surface, the spinal cord and the cranial nerves. The pigment
is deposited as a result of chronic bleeding in the subarachnoid space.
This produces a clinical picture of deafness, ataxia, cranial nerve
deficits and in the latest stages dementia. In some cases the source of
bleeding can be identified, whilst in others it can not. Despite its
rarity the disease should be considered in the differential diagnosis
of sensorineural deafness, particularly as it is a progressive and in
some cases curable disease which is easily diagnosed by magnetic
resonance imaging (MRI). In this case report the haemosiderin was
derived from an ependymoma of the fourth ventricle with extension into
the cerebello-pontine angle. The first symptom was a worsening
sensorineural hearing loss.

Publication Types:
Case Reports

PMID: 9292135 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------

<<snip>>
high accumulation of iron in brain tissue
causes oxidative damage and formation of plaques found in age-related
neurodegenerative disorders such as Alzheimer disease
<<snip>>

Public release date: 24-Mar-2006
http://www.eurekalert.org/pub_releases/2006-03/uoc--mso032106.php


Contact: Dan Page
d...@xxxxxxxxxxxxxxx
310-794-2265
University of California - Los Angeles


MRI study opens door to assessing, preventing dangerous brain iron
levels


A magnetic resonance imaging (MRI) study at UCLA opens new doors to
assessing and potentially preventing brain iron accumulation associated

with risk of developing degenerative brain diseases such as
Alzheimer's,
Parkinson's and Dementia With Lewy Bodies.


Posted as an early online publication of the peer-reviewed journal
Neurobiology of Aging, this largest-ever study of brain iron
demonstrates
gender difference in brain iron levels for the first time. Until now,
researchers had considered the brain blood barrier as protection
against
accumulating too much iron from the body. The finding suggests instead
that age-related brain iron accumulation is a modifiable risk factor
for
degenerative brain diseases.


In addition, the study finds a nearly perfect correlation between iron
levels in various brain regions of study participants measured using
MRI
and those reported by past post-mortem studies. The finding
demonstrates
the ability of MRI analysis to accurately measure iron levels in brain
tissues of living patients.


Previous studies have shown that high accumulation of iron in brain
tissue
causes oxidative damage and formation of plaques found in age-related
neurodegenerative disorders such as Alzheimer disease. In addition,
past
population studies show men develop such diseases about five years
earlier
than women but brain iron levels increase with age in both genders.


"If you can measure it and learn how to modify it, then you can fix
it,"
said Dr. George Bartzokis, lead author and professor of neurology at
the
David Geffen School of Medicine at UCLA. "Alzheimer disease rates
double
every five years after age 60, so a modifiable risk factor assessed by
non-invasive means may represent potential interventions that could
halve
the number of cases of AD in the United States."


The UCLA team measured iron stored in ferritin molecules in the brain
tissues of living subjects with MRI by using the Field Dependent
Relaxation Rate Increase (FDRI) method. Iron was measured in four
subcortical tissues, three white matter regions and the hippocampus of
165
healthy adults, ages 19 to 82.


In addition to the nearly perfect correlation between published
post-mortem brain iron levels and those measured by FDRI, the study
found
that men have significantly higher ferritin iron than women in two
subcortical regions and all three white matter regions.


The team also found significant age-related increases in ferritin iron
in
the hippocampus and three of the four subcortical regions, and
decreases
in one white matter region.


http://www.eurekalert.org/pub_releases/2006-03/uoc--mso032106.php


Subject: RE: soil remediation


Capturing Heavy Metals


Argonne chemists have begun laboratory testing of a new technology to
limit the movement of hazardous radionuclides through the environment.
The
technology is designed to capture heavy metals, such as uranium and
plutonium,
and reduce their solubility, thus keeping them from being transported
in
groundwater. It uses phytic acid, a natural chelating agent
which captures the heavy metal ion through a process called a
cation exchange. In this process, one atom or group of atoms in the
agent
swaps places with the heavy metal atoms in the contaminated material.
Phytic
acid has the added advantage of spontaneously decomposing over time,
releasing
phosphate - which joins with the heavy metal ions to form an insoluble
mineral
- and harmless sugars.


If successful, the technology would be used to treat contaminated soil
at U.S. Department of Energy production facilities. The research is
funded
by the Efficient Separations and Processes Program at DOE.


Funding for the research is provided by the U.S. Department of Energy's

Office of Basic Energy Sciences, Division of Chemical Sciences.


------------------------------------------------------------------------------------

http://www.indianpediatrics.net/oct2005/oct-998-1005.htm


Indian Pediatrics 2005; 42:998-1005


Transcutaneous Absorption of Topically Massaged Oil in Neonates


Kirti Solanki, Manoj Matnani, +Mrudula Kale, +Kalpana Joshi, Ashish
Bavdekar, Sheila Bhave and Anand Pandit



From the *Department of Pediatrics, KEM Hospital, Pune 411 011, India


and +School of Health Sciences, University of Pune, Pune 411 007,
India.

Address for Correspondence : Dr. Sheila Bhave, Department of
Pediatrics, KEM Hospital, Pune 411 011, India. E-mail: kem...@xxxxxxxx


Abstract


Objective: To study the transcutaneous absorption of traditionally
massaged oil in newborns and to specifically compare the effects of (i)



essential fatty acid (EFA) rich - safflower oil and (ii) saturated fat
rich coconut oil, on fatty acid profiles of massaged babies. Design: A
short term randomised controlled study. Setting: Tertiary care NICU of
a large teaching hospital and a research laboratory of a University
complex. Methods: 120 study babies were randomly assigned to three oil
groups (i) safflower oil (n = 40) (ii) coconut oil (n = 40) and (iii)
no oil controls (n = 40). In each group, babies were selected in three
subsets as per their gestational ages viz., (a) <34weeks, (b) 34-37
weeks, (c) > 37 weeks. 5 mL of the designated oil was massaged four
times a day (6hrly) for five days under controlled conditions of
temperature and feeding. Pre and post oil massage samples of blood were



analysed for triglycerides and fatty acid profiles using gas
chromatography. Results: Post oil triglyceride values were
significantly raised in both the oil groups and also in controls.
However, the quantum of rise was significantly higher in oil groups as
compared to controls (p <0.05). Fatty acid profiles (gas
chromatography) showed significant rise in EFAs (linolenic acid and
arachidonic acid) in safflower oil group and saturated fats in coconut
oil group (p <0.05). Changes were more evident in term babies. There
were no side effects associated with the massage. Conclusion: This
study shows that topically applied oil can be absorbed in neonates and
is probably available for nutritional purposes. The fatty acid
constituents of the oil can influence the changes in the fatty acid
profiles of the massaged babies.


Key words: Fatty acid profile, Topical absorption, Traditional oil .

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

.

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