What would it take to convert ISS to an interplanetary mission?



I know, ISS is doomed to be ditched in less than ten years,
but just as an intellectual excercise what would it take to
make ISS into a Mars or Lunar-bound craft?

My thoughts would be one or more ion thrusters powered with
a nuclear source like the Topaz, lots of outside storage for
breathing gases and food, etc. From a technical standpoint,
what would it take?

JazzMan
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