Re: HELP: meta-analysis on only two studies

On Apr 27, 5:17 am, SmileDomain <enthume...@xxxxxxxx> wrote:
Recently I am working to do a meta-analysis on some kind of gene-
disease. Since there are only two studies include in my work, it is
impossible to do a meta-regression. And the fixed effected model and
radom affected model are useless too. There are few studies focusing
on this topic, can any one give a sugguestion?


What prevents you from computing a pooled estimate in the usual
fashion? If I'm not mistaken, the usual chi-square test of
heterogeneity would be equivalent to the square of a z-test comparing
the estimates from the two individual studies.


ps. I have not only the published data, but also the original data.
But they are so different, one meet the HWE perfectly, while the Chi-2
of another study is larger than 10.

What is HWE? What kind of data are you talking about? Odds ratios
from 2x2 tables? Or something else?

--
Bruce Weaver
bweaver@xxxxxxxxxxxx
www.angelfire.com/wv/bwhomedir
"When all else fails, RTFM."
.